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MDM2 pAb

MDM2 pAb

Cat no: BS6818


Supplier: Bioworld Technology, Inc.
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MDM2, a ubiquitin ligase for p53, plays a central role in regulation of the stability of p53. Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53. Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53.
Catalogue number: BS6818
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug/100ul
Swiss prot: Q00987
Dilutions: WB: 1:500~1:2000
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Recombinant full length Human MDM2.
Species: MDM2 pAb detects endogenous levels of MDM2 protein.
Molecular weight: ~ 55,90 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: MDM2; HDMX; MGC5370; MGC71221; hdm2;
Additional info: For research use only, not for use in diagnostic procedure.

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