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Microcephalin Peptide

Cat no: BS5900P

Microcephalin Peptide

Microcephalin (MCPH1, BRCT-repeat inhibitor of TERT expression 1, BRIT1) modulates brain size and has been proliferating under strong positive selection for several thousand years, although the nature of the positive selection is poorly understood. Human Microcephalin contains three BRCA1 C-terminal (BRCT) domains and shares 57% identity with its mouse ortholog, the most conserved regions being BRCT domains where there is 80% identity. Predominant expression of human Microcephalin is observed in fetal brain, liver and kidney tissues and is expressed during neurogenesis in mice. Microcephalin displays significantly higher rates of protein evolution in primates than in rodents; this trend is most noticeable for the subset of genes associated with nervous system development. Microcephalin has a very young, single nucleotide, polymorphism haplotype associated with modern humans; this gene is presumably still evolving in Homo sapiens. It functions in DNA damage response and regulation of cell cycle checkpoints.

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SPECIFICATIONS

Catalog Number

BS5900P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide Microcephalin. (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

Q8NEM0

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS5900 Microcephalin pAb.

Alternative Names

MCPH1; BRCT-repeat inhibitor of TERT expression 1; BRIT1

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