MMP15, NT (Matrix Metalloproteinase-15, MMP-15, Membrane-type Matrix Metalloproteinase 2, MT-MMP 2, MTMMP2, Membrane-type-2 Matrix Metalloproteinase, MT2-MMP, MT2MMP, SMCP-2) (PE)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, MMP15 is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted.\n\nApplications: \nSuitable for use in ELISA, Western Blot, Flow Cytometry, and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1:100-1:500\nELISA: 1:1,000\nImmunohistochemistry: 1:50-1:100 \nFlow Cytometry: 1:10-1:50\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze R-Phycoerythrin conjugates. Light sensitive. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

M2430-03C-PE

Size

200ul

Applications

ELISA, FC, IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to R-Phycoerythrin (R-PE).

P Type

Pab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG

References

1.Jung, M., et al., Prostate 55(2):89-98 (2003). 2.Nagase, H., et al., J. Biol. Chem. 274(31):21491-21494 (1999). 3.d'Ortho, M.P., et al., Eur. J. Biochem. 250(3):751-757 (1997). 4.Sato, H., et al., Genomics 39(3):412-413 (1997). 5.Mattei, M.G., et al., Genomics 40(1):168-169 (1997).

Additional Info

Recognizes human MMP15. Species Crossreactivity: mouse.