MMP7 (Matrin, Matrix metalloproteinase-7)

MMP7,matrix metalloproteinase-7, is an enzyme that in humans is encoded by the MMP7 gene. The MMP7 protein has 267 amino acids and is significantly shorter than stromelysin or collagenase. By Southern and PCR analysis of 2 different panels of somatic cell hybrids and by isotopic in situ hybridization, the MMP7 gene is mapped to 11q21-q22. It is a member of matrix metalloproteinase family. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa.\n\nUniProt Number:\nQ10738\n\nGene ID:\nMMP7\n\nApplications:\nSuitable for use in Western Blot and Immunohistochemistry (Paraffin).\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Handling:\nStore at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term.\nAvoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

144915

Size

100ug

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Mouse, Rat

Form

Supplied as a lyophilized powder. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Crawford, H. C., Scoggins, C. R., Washington, M. K., Matrisian, L. M., Leach, S. D.Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas.J. Clin. Invest. 109: 1437-1444, 2002.\n2. Knox, J. D., Boreham, D. R., Walker, J.-A., Morrison, D. P., Matrisian, L. M., Nagle, R. B., Bowden, G. T.Mapping of the metalloproteinase gene matrilysin (MMP7) to human chromosome 11q21-q22.Cytogenet. Cell Genet. 72: 179-182, 1996.\n3. Muller, D., Quantin, B., Gesnel, M.-C., Millon-Collard, R., Abecassis, J., Breathnach, R.The collagenase gene family in humans consists of at least four members.Biochem. J. 253: 187-192, 1988.\n

Additional Info

Recognizes mouse and rat MMP7. No crossreactivity with other proteins.