Interferon-inducible proteins include IFI-202, IFI-203, IFI-204 and D3, which are encoded by six or more structurally related and IFN-inducible mouse genes mapping at the q21-q23 region of chromosome 1. The proteins encoded by these genes have homologous 200 amino acid segments. IFI-202 is a 52 kDa, primarily nuclear phosphoprotein which inhibits cell growth, in part by modulating transcriptional activity of NFkB, E2F, AP-1 and p53. Two related human proteins, MNDA (myeloid cell nuclear differentiation antigen) and IFI-16, have also been described. Expression of MNDA has been observed specifically in cells of the granulocyte-macrophage lineage. IFI-16 is constitutively expressed in various T and B cell lines and can be induced by IFN-gamma in HL60 cells. At least four of the Gene 200 cluster of IFN-inducible proteins, IFI-202, IFI-204, MNDA and IFI-16, are localized in the nucleus.