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MRCK(beta) (F1665) pAb

MRCK(beta) (F1665) pAb

Cat no: BS2382

Supplier: Bioworld Technology, Inc.
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Protein kinases comprise a large group of encoded factors that regulate cellular processes by catalyzing the transfer of a phosphate group to a hydroxyl acceptor in serine, threonine or tyrosine residues. Myotonic dystrophy kinaserelated Cdc42-binding (DMPK-like) kinases-(alpha) and (beta) (MRCK-(alpha), (beta)) contain a cysteine-rich motif and a putative pleckstrin homology domain. MRCKs can phosphorylate nonmuscle Myosin light chain and influences Actin-Myosin contractility. MRCK-(alpha) can phosphorylate and activate LIM kinases downstream of Cdc42, which leads to inactivation of ADF/Cofilin and to Actin cytoskeletal reorganization. MRCK-(alpha) can also influence neurite outgrowth promoted by Cdc42 and Rac.
Catalogue number: BS2382
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: Q9Y5S2
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 1630-1680 of Human MRCK(beta).
Species: MRCK(beta) (F1665) pAb detects endogenous levels of MRCK(beta) protein.
Molecular weight: ~ 194 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: MRCK(beta); CDC42BPB; KIAA1124; MRCK beta
Additional info: For research use only, not for use in diagnostic procedure.

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