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MRP1 (Multidrug Resistance-associated Protein 1, ATP-binding Cassette Sub-family C Member 1, Leukotriene C(4) Transporter, LTC4 Transporter, MRP, ABCC1)

Cat no: M4688-18G

MRP1 (Multidrug Resistance-associated Protein 1, ATP-binding Cassette Sub-family C Member 1, Leukotriene C(4) Transporter, LTC4 Transporter, MRP, ABCC1)

Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.\n\nApplications:\nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:128,000\nWestern Blot: 0.05-0.2ug/ml, observed in lysates of cell line A549 on ~150kD bands\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

M4688-18G

Size

100ug

Applications

ELISA, WB

Hosts

Goat

Reactivities

Hum, Mouse, Rat, Bov, Can

Form

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

References

1. Bobrowska-H

Additional Info

Recognizes human ABCC1. Species sequence homology: Bovine, canine, mouse and rat.

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