MRP8 (Migration inhibitory factor-related protein 8, 60B8AG, CAGA, Calgranulin-A, Calprotectin L1L subunit, CFAG, CGLA, CP-10, Cystic fibrosis antigen, L1Ag, Leukocyte L1 complex light chain, MA387, MIF, MRP-8, NIF, P8, Protein S100-A8, S100 calcium-bindi

MRP-8 and MRP-14 are cytosolic calcium-binding proteins of 8kD and 14kD that form a heterodimer. MRP-8 and MRP-14 are expressed in peripheral blood monocytes, neutrophils and keratinocytes (particularly in psoriasis). Expression is lost on tissue maturation of monocytes to macrophages. MRP-14 may be associated with monocyte and neutrophil activation and the accumulation of these cells in inflammatory sites. Altered expression of MRP8 is associated with the disease cystic fibrosis.\n\nApplications: \nSuitable for use in Flow Cytometry, ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilutions:\nOptimal dilutions to be determined by the researcher.\n\nPositive Control: \nNeutrophil lysate, particularly neutrophils from spleen.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

M4688-36A

Size

100ug

Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS.

P Type

Mab

Purity

Purified

Isotype

IgM

References

1. Robinson MJ et al. The S100 family heterodimer, MRP-8/14, binds with high affinity to heparin and heparan sulfate glycosaminoglycans on endothelial cells. J Biol Chem 277:3658-3665 (2002).

Additional Info

Recognizes human MRP8 at ~8kD.

Alternative Names

Migration inhibitory factor-related protein 8, 60B8AG, CAGA, Calgranulin-A, Calprotectin L1L subunit, CFAG, CGLA, CP-10, Cystic fibrosis antigen, L1Ag, Leukocyte L1 complex light chain, MA387, MIF, MRP-8, NIF, P8, Protein S100-A8, S100 calcium-binding protein A8, Urinary stone protein band A