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MSH6 / GTBP (E371) Peptide

MSH6 / GTBP (E371) Peptide

Cat no: BS2420P

Supplier: Bioworld Technology, Inc.
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The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. A member of the mismatch repair family, GTBP (also designated MSH6), is a 160 kDa MSH2-related protein that binds to DNA containing G/T mismatches. Findings suggest that the mismatch-binding factor in human cells is composed of a heterodimer of GTBP and MSH2.
Catalogue number: BS2420P
Applications: Block/Neutralize/Inhibit
Swiss prot: P52701
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide MSH6 / GTBP (E371). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: MSH6; GTBP; GTMBP; HNPCC5; HSAP; P160
Additional info: This peptide can be used with studies using BS2420 MSH6 / GTBP (E371) pAb.

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