Mycoplasma Removal Agent

Mycoplasma Removal Agent (MRA) has been developed for cell culture, to combat the widespread problems caused by contamination of cell cultures with mycoplasma.\n\nMycoplasma Removal Agent is very effective at removing mycoplasma from infected cell cultures. It shows a strong anti-mycoplasma activity against many types of mycoplasma including Mycoplasma orale, M. arginini, M. hyorhinis and Acholeplasma laidlawii. MRA is suitable for use after the removal of mycoplasma, to prevent recontamination of the culture with the original mycoplasma, at preventative doses. MRA can also be used to prevent initial infection of cells in culture by mycoplasma. MRA is non-toxic, and will not interfere with the viability or function of cells in culture.\n\nMRA is very easy to use, simply requiring incubation for a week after addition to cell cultures contaminated by mycoplasma. It should be emphasised that MRA should not be used as a substitute for good cell culture techniques.\n\nIndications for Use:\n1. Add MRA to cell cultures contaminated by mycoplasma at a concentration of 0.5ug/ml and\nincubate for a week.\n2. For media replacement or culture transfer (passage), use a medium containing MRA at this\nsame concentration.\n3. Transfer the cell cultures several times without MRA and confirm that regrowth of the\ncontaminating mycoplasma has not occurred.\n\nIf there is a concern about the presence of mycoplasma in serum or trypsin, MRA can be added to the media at a concentration of 0.5ug/ml to prevent contamination of the cell cultures exposed to these products.\n\nConcentration may be raised up to 1ug/ml only when the recommended concentration is ineffective in removing the mycoplasma. The cytotoxicity of MRA is low and cell toxicity is rare when used at the recommended concentration. For specific function of any cell, however, it is recommended that the retention of desired cellular characteristics be confirmed after treatment.\n\nStorage and Stability: \nMRA is stable at room temperature. Protect from light to prevent decomposition. Stable for 12 months.

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