Myelin Basic Protein, aa4-14

Myelin basic protein (MBP) is a single-chain, flexible polypeptide of about 18.5kD existing in its natural environment as an extrinsic and loosely bound component of the cytoplasmic portion of the myelin membrane sandwich. Ultrastructural immunocytochemistry with anti-myelin basic protein has shown that MBP is localized in the compact myelin sheath. MBP has not been demonstrated in rough endoplasmic reticulum, lysosomes or any other cytoplasmic organelles (3). MBP serves as a marker for oligodendrocytes and Schwann cells (3). MBP is also a marker for malignant schwannomas (4) and appears to play a significant role in the etiology of multiple sclerosis (5

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SPECIFICATIONS

Catalog Number

M9758-03K

Size

1mg

Form

Supplied as a lyophilized powder.

Purity

~90% by HPLC and MS analysis

References

1. Farrar, Y.J.K., et al., Biochem. Biophys. Res. Commun. 180(2): 694-701 (1991). 2. Day, E.D. and N.T. Potter, J. Neuroimmunol. 10: 289 (1986). 3. Hashim, G.A., Immunol. Rev. 39: 60 (1978). 4. Golo, M., Histochemistry 87: 201 (1987). 5. Mogollon, R., et al., Cancer 53: 1190 (1984). 6. Whitaker, J.N., Ann. N.Y. Acad. Sci. 436: 140 (1984). 7. Eidinoff, H., Med. Hypotheses 26: 103 (1988). 8. tar Meulen, V., Ann. N.Y. Acad. Sci. 540: 202 (1988). 9. Kerlero de Rosbo, N., et al., J. Neuroimmunol. 9: 349 (1985). 10. Sires, L.R., et al., Science 214: 87 (1981).