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MYH (Y176) Peptide

Cat no: BS2535P

MYH (Y176) Peptide

MYH (mutY homolog (E. coli )) is a DNA glycosylase mismatch repair enzyme that in conjunction with mutM (OGG1), cleaves adenine residues paired with either oxidized (8-hydroxyguanines) or non-modified guanines in order to correct A/G and A/C mismatches. Repair of most modified and mispaired bases in the genome is initiated by DNA glycosylases, which bind and cleave N-glycosyl bonds to initiate base excision repair. MYH is crucial for the avoidance of mutations resulting from oxidative DNA damage. Multiple N-terminal splice variants of MYH exist in mammalian cells. Increasing levels of MYH in A549 cells exposed to oxygen and infrared radiation leads to improvements in cell survival. Biallelic MYH germ-line mutations predispose humans to colorectal adenomas and carcinomas. MYH is abundant in neurons where mitochondrial genomes exposed to reactive oxygen species (ROS) that damage DNA must maintain integrity over the entire mammalian life span.

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SPECIFICATIONS

Catalog Number

BS2535P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide MYH (Y176). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

Q9UIF7

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS2535 MYH (Y176) pAb.

Alternative Names

MYH; EC 3.2.2.-; MutY homolog; hMYH; MYH; 4595; MUTYH; 132600; Q9UIF7; MYH; MYHbeta; hMYH;

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