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N-CoR (H76) Peptide

Cat no: BS1462P

N-CoR (H76) Peptide

Retinoids are metabolites of vitamin A (retinol) and are believed to represent important signaling molecules during vertebrate development and tissue differentiation.Two families of retinoid receptors have been identified. Retinoic acid receptors (RARs), include RARalpha, RARbeta and RARgamma , each of which have a high affinity for all-trans retinoic acids and belong to the same class of nuclear transcription factors as thyroid hormone receptors, vitamin D3 receptor and ecdysone receptor. Two cofactors that function to repress transcription, designated SMRT and N-CoR, have been shown to associate with the thyroid receptor and RAR in their unliganded state and are released from them upon ligand binding. The carboxy termini of both proteins contain receptor interacting domains while their amino termini contain two previously undescribed repressor domains. SMRT (silencing mediator for RARs and TRs) is 1495 amino acids in length with an estimated molecular weight of 168 kDa. N-CoR (nuclear receptor corepressor) is a protein 2453 amino acids in length with a relative molecular weight of 270 kDa.

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SPECIFICATIONS

Catalog Number

BS1462P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide N-CoR (H76). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

O75376

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS1462 N-CoR (H76) pAb.

Alternative Names

NCOR1; HCIT529I10; HN-COR; KIAA1047; MGC104216; N-COR; N-COR1; TRAC1

SUPPLIER INFO

Bioworld Technology, Inc.

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