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N-myc 1 (Myc, myc-1)

Cat no: N2915-04

N-myc 1 (Myc, myc-1)

Myc proteins have documented oncogenic potential and similar DNA binding properties. Studies indicate that inhibiting N-myc gene expression results in either the suppression of cell proliferation or the induction of differentiation and/or apoptosis. The oncogene v-myc was first identified as the transforming gene of the avian myelocytomatosis retrovirus MC29 (hence the name myc). Five members of the human myc family of nucleus-associated phosphoproteins (c-, N-, L-, B-, and R-myc) are currently known. The N-myc gene gives rise to at least two nuclear phosphoproteins of 64kD and 67kD with a relatively short half life (30 minutes) in vivo and exhibit DNA binding properties in vitro. Amplification of the N-myc gene has been reported in human neuroblastomas and cell lines. For example, ampli?cation of the N-Myc gene is associated with a poor prognosis in some neuroblastomas. Myc proteins are potent transcriptional activators that regulate gene expression by forming heterodimers with Max and binding speci?cally to CAC(G/A)TG sequence motifs in target genes. Max proteins can also form homodimers that recognize the same DNA motif as the Myc/Max heterodimer. Max homodimers, however, repress transcription. The extent of N-myc amplification correlates well with the stage of neuroblastoma disease.\n\nPositive control: Neuroblastoma cell lines and tumors.\n\nCellular Localization: Predominantly nuclear, some cytoplasmic.

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SPECIFICATIONS

Catalog Number

N2915-04

Size

100ug

Applications

ELISA

Hosts

Mouse

Reactivities

Hum, Mouse

Form

Supplied as a liquid in PBS, pH 7.2.

P Type

Mab

Isotype

IgG2a

References

Kolodziej, P.A. and Young, R.A. \"Epitope tagging and protein surveillance.\" Methods Enzymology. 194: 508-519, 1991.\n

Additional Info

Specific for N-Myc. No cross-reaction with c-myc or L-myc. Species crossreactivity: Reacts with human and mouse N-myc.

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