Na+ CP type (alpha)-pan (E1476) pAb

Voltage-gated Na+ channels regulate the permeability of excitable cells to sodium ions. During the propagation of an action potential, Na+ channels allow an influx of sodium ions, which rapidly depolarize the cell. The sodium channel protein is comprised of one (alpha) subunit and two (beta) subunits. The Na+ CP type I and Na+ CP type II(alpha) subunits are expressed in adult brain. Na+ CP type III(alpha) is expressed in embryonic brain, but not in adult brain. Na+ CP type III(beta) is a 215 amino acid, single-pass type I membrane protein that modulates sodium channel gating kinetics and inactivates the channel opening more slowly than the I(beta) subunit. It has an extracellular N-terminal domain, an N-terminal signal sequence, a single membrane-spanning region and a C-terminal cytoplasmic region.

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SPECIFICATIONS

Catalog Number

BS3558

Size

100ug/100ul

Applications

IHC

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 1442-1496 of Human Na+ CP type (alpha)-pan.

Species

Na+ CP type (alpha)-pan (E1476) pAb detects endogenous levels of Na+ CP type (alpha)-pan protein.

Dilutions

IHC: 1:50~1:200

Swiss Prot

Q15858

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 226 kDa

Alternative Names

ETHA; hNE Na; hNE-Na; hNENa; NE NA; NENA; Neuroendocrine sodium channel; Peripheral sodium channel 1; PN1; SCN9A; SCN9A; Sodium channel protein type 9 subunit alpha; Sodium channel protein type IX subunit alpha; Sodium channel voltage gated type IX alpha; Sodium channel voltage gated type IX alpha polypeptide; Sodium channel voltage gated type IX alpha subunit; Voltage gated sodium channel alpha subunit Nav1.7; Voltage gated sodium channel subunit alpha Nav1; Voltage-gate