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Na+ CP type IV(alpha) pAb

Na+ CP type IV(alpha) pAb

Cat no: BS5812

Supplier: Bioworld Technology, Inc.
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Voltage-gated sodium channels are selective ion channels that regulate the permeability of sodium ions in excitable cells. During the propagation of an action potential, sodium channels allow an influx of sodium ions, which rapidly depolarize the cell. The three glycoproteins that comprise the voltagegated sodium channel proteins include a pore-forming (alpha) subunit, a noncovalently associated (beta)1 subunit and a disulfide-linked (beta)2 subunit. The two (beta) subunits regulate the level of channel expression, modulate gating and function as cell adhesion molecules for cellular aggregation and cytoskeleton interaction. The (alpha) subunits of sodium channels type I and III are predominantly expressed in neuronal cell bodies and proximal processes, while type II(alpha) subunits are more abundant along axons. The (beta)1 subunit of sodium channel type I is expressed in brain, skeletal and cardiac muscle. In the brain, (beta)1 and (beta)2 are highly expressed in Purkinje cells, and (beta)1 is also expressed in the pyramidal cells of the deep cerebellar nuclei. Impaired voltage-gated sodium channels lead to a number of diseases including myotonia.
Catalogue number: BS5812
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug/100ul
Swiss prot: P35499
Dilutions: WB: 1:500~1:1000
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 472-517 of Human Na+ CP type IV(alpha).
Species: Na+ CP type IV(alpha) pAb detects endogenous levels of Na+ CP type IV(alpha) protein.
Molecular weight: ~ 208 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Sodium channel protein type 4 subunit alpha; SkM1; Sodium channel protein skeletal muscle subunit alpha; Sodium channel protein type IV subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.4; SCN4A
Additional info: For research use only, not for use in diagnostic procedure.

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