Na+ CP type IX(alpha) pAb

Cat no: BS5813

Supplier: Bioworld Technology, Inc.

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Voltage-gated sodium channels are selective ion channels that regulate the permeability of sodium ions in excitable cells. During the propagation of an action potential, sodium channels allow an influx of sodium ions, which rapidly depolarizes the cell. Na+ CP type IX(alpha), also known as SCN9A (sodium channel protein type 9 subunit (alpha)), NENA, PN1, Nav1.7 or ETHA, is a 1,988 amino acid multi-pass membrane protein that belongs to the voltage-gated sodium channel family. Expressed in dorsal root ganglion, smooth muscle cells and in the central and peripheral nervous system, Na+ CP type IX(alpha) functions to mediate the voltage-dependent sodium ion permeability of membranes, specifically forming a sodium-selective ion channel through which sodium may pass. Via its ability to control the flow of sodium in and out of excitable membranes, Na+ CP type IX(alpha) plays an important role in the inflammatory pain response. Defects in the gene encoding Na+ CP type IX(alpha) are the cause of primary erythermalgia, autosomal recessive congenital indifference to pain and paroxysmal extreme pain disorder (PEPD), all of which are genetic pain disorders.

Catalogue number:	BS5813
Reactivities:	Human, Mouse, Rat
Hosts:	Rabbit
Applications:	Western Blot
Size:	100ug/100ul
Swiss prot:	Q15858
Dilutions:	WB: 1:500~1:1000
Form:	liquid
Storage buffer:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration:	1ug/ul
Antigen:	Synthetic peptide, corresponding to amino acids 702-747 of Human Na+ CP type IX(alpha).
Species:	Na+ CP type IX(alpha) pAb detects endogenous levels of Na+ CP type IX(alpha) protein.
Molecular weight:	~ 226 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp:	Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names:	Sodium channel protein type 9 subunit alpha; Neuroendocrine sodium channel; hNE-Na; Peripheral sodium channel 1; PN1; Sodium channel protein type IX subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.7; SCN9A; NENA
Additional info:	For research use only, not for use in diagnostic procedure.

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Na+ CP type IX(alpha) pAb

Cat no: BS5813

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