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Na+ CP type VIII(alpha) pAb

Na+ CP type VIII(alpha) pAb

Cat no: BS60365

Supplier: Bioworld Technology, Inc.
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The sodium channel protein type 8 subunit alpha (Na+ CP type VIII(alpha) ) is a multi-pass, transmembrane protein that mediates the sodium ion permeability of excitable membranes. The three glycoproteins that comprise the voltage-gated sodium channel proteins include a pore-forming (alpha) subunit, a noncovalently associated (beta)1 subunit and a disulfide-linked (beta)2 subunit. The two (beta) subunits regulate the level of channel expression, modulate gating and function as cell adhesion molecules for cellular aggregation and cytoskeleton interaction. The (alpha) subunits of sodium channels type I and III are predominantly expressed in neuronal cell bodies and proximal processes, while type II(alpha) subunits are more abundant along axons. Sodium channels are important for rapid signal transduction but also play a significant role in neuronal development. Defects of the SCN8A gene have exhibited detrimental effects on the growth of secondary motoneurons. Loss of SCN8A expression will result in progressive paralysis and early death.
Catalogue number: BS60365
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug/100ul
Swiss prot: Q9UQD0
Dilutions: WB: 1:500~1:1000
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: A synthetic peptide corresponding to residues in Human Na+ CP type VIII(alpha).
Species: Na+ CP type VIII(alpha) pAb detects endogenous levels of Na+ CP type VIII(alpha) protein.
Molecular weight: ~ 225 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Sodium channel protein type 8 subunit alpha; Sodium channel protein type VIII subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.6; SCN8A; MED
Additional info: For research use only, not for use in diagnostic procedure.

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