Na+ CP type VIII(alpha) pAb

The sodium channel protein type 8 subunit alpha (Na+ CP type VIII(alpha) ) is a multi-pass, transmembrane protein that mediates the sodium ion permeability of excitable membranes. The three glycoproteins that comprise the voltage-gated sodium channel proteins include a pore-forming (alpha) subunit, a noncovalently associated (beta)1 subunit and a disulfide-linked (beta)2 subunit. The two (beta) subunits regulate the level of channel expression, modulate gating and function as cell adhesion molecules for cellular aggregation and cytoskeleton interaction. The (alpha) subunits of sodium channels type I and III are predominantly expressed in neuronal cell bodies and proximal processes, while type II(alpha) subunits are more abundant along axons. Sodium channels are important for rapid signal transduction but also play a significant role in neuronal development. Defects of the SCN8A gene have exhibited detrimental effects on the growth of secondary motoneurons. Loss of SCN8A expression will result in progressive paralysis and early death.

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SPECIFICATIONS

Catalog Number

BS60365

Size

100ug/100ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

A synthetic peptide corresponding to residues in Human Na+ CP type VIII(alpha).

Species

Na+ CP type VIII(alpha) pAb detects endogenous levels of Na+ CP type VIII(alpha) protein.

Dilutions

WB: 1:500~1:1000\r

Swiss Prot

Q9UQD0

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 225 kDa

Alternative Names

Sodium channel protein type 8 subunit alpha; Sodium channel protein type VIII subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.6; SCN8A; MED