Na+/K+-ATPase (alpha)1 (A254) pAb

The ubiquitously expressed sodium/potassium-ATPase (Na+/K+-ATPase) exists as a oligomeric plasma membrane complex that couples the hydrolysis of one molecule of ATP to the importation of three Na+ ions and two K+ ions against their respective electrochemical gradients. As a member of the P-type family of ion motives, Na+/K+-ATPase plays a critical role in maintaining cellular volume, resting membrane potential and Na+-coupled solute transport. Multiple isoforms of three subunits, (alpha), (beta) and (gamma), comprise to form the Na+/K+-ATPase oligomer. The (alpha) subunit contains the binding sites for ATP and the cations; the glycosylated (beta) subunit ensures correct folding and membrane insertion of the (alpha) subunits. The small (gamma) subunit co-localizes with the (alpha) subunit in nephron segments, where it increases the affinity of Na+/K+-ATPase for ATP.

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SPECIFICATIONS

Catalog Number

BS3190

Size

100ug/100ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 221-270 of Human Na+/K+-ATPase (alpha)1.

Species

Na+/K+-ATPase (alpha)1 (A254) pAb detects endogenous levels of Na+/K+-ATPase (alpha)1 protein.

Dilutions

WB: 1:500~1:1000

Swiss Prot

P06685

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul