Nafarelin Acetate (NAF)

Nafarelin acetate is a synthetic analog of the naturally occurring gonadotropin-releasing hormone (GnRH). Nafarelin stimulates the release of the pituitary gonadotropins, LH and FSH, resulting in a temporary increase of ovarian steroidogenesis.\n\nNafarelin is a decapeptide containing 9 amino acids Glu-His-Trp-Ser-Ala-Leu-Arg-Pro Nafarelin is purified by proprietary chromatographic techniques.\n\nProtein Content:\nProtein quantitation was carried out by two independent methods:\n1. UV spectroscopy at 280nm. \n2. Analysis by RP-HPLC, using a standard solution of Nafarelin as a Reference Standard.\n\nReconstitution:\nReconstitute the lyophilized Nafarelin in sterile 18MOmega-cm H2O not less than 100ug/ml, which can then be further diluted to other aqueous solutions.\n\nStorage and Stability:\nLyophilized powder may be stored at 4 degrees C for short-term only. Reconstitute to nominal volume by adding sterile dH2O and store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

N0015-60

Size

8mg

Form

Supplied as a lyophilized powder. No additives.

Purity

(same/more than) 95% by RP-HPLC, FPLC, or reducing/non-reducing SDS-PAGE Silver Stain. Chromatographically purified.

References

1. Dose of GnRH agonist (nafarelin acetate) affects intrafollicular PAPP-A expression in controlled ovarian hyperstimulation cycle. Suh J, Lee E, Yoon S, Eur J Obstet Gynecol Reprod Biol 2004 Jan 15;112(1):65-8 2. A prospective randomized comparison of routine buserelin acetate and a decreasing dosage of nafarelin acetate with a low-dose gonadotropin-releasing hormone agonist protocol for in vitro fertilization and intracytoplasmic sperm injection. Takeuchi S, Minoura H, Tsuiki Y, Fertil Steril 2001 Sep;76(3):532-7 3. [Nafarelin acetate (Synarel) and thermocoagulation in the treatment of endometriosis] Palatynski A, Gruszczynska J, Ginekol Pol 2001 May;72(5):284-9 4. [Treatment of pelvic endometriosis with goserelin acetate or nafarelin acetate. Comparative study] Calvo Lugo GE, Sauceda Gonzalez LF, Diaz Arias FJ, Ginecol Obstet Mex 2000 Jan;68:7-14 5. Crohn's disease mimicking as bowel endometriosis. Are the symptoms reduced by nafarelin acetate? Nakao A, Iwagaki H, Jikuhara A, Tanaka N, Arch Gynecol Obstet 2000 Feb;263(3):131-3 6. Nafarelin acetate for pituitary suppressions in in-vitro fertilisation cycles--a Singaporean experience. Loh SK, Leong NK, Singapore Med J 1999 Dec;40(12):752-5.