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NCX1 (Sodium Calcium Exchanger)

Cat no: N0560-20A

NCX1 (Sodium Calcium Exchanger)

The expression and protein levels of the Na(+)/Ca(2+) exchanger (NCX-1) vary during heart development and in response to changes in thyroid hormone levels (1). The expression of the NCX-1 gene is two-fold higher in the fetal heart of mouse versus adult. In addition, NCX-1 mRNA and protein levels were upregulated in hypothyroidic hearts. In hyperthyroidic hearts this response was reversed, however.\n\nMay be used for western analysis and immunohistochemistry. Recommended Dilution: Western Blot 1:200 Immunohistochemistry 1:1000

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SPECIFICATIONS

Catalog Number

N0560-20A

Size

100ug

Applications

IHC, WB

Hosts

Mouse

Reactivities

Rabbit

Form

Supplied as a lyophilized powder. Reconstitute in 200ul of PBS.

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG2b

References

1. Reed, T.D., et al. The expression of SR calcium transport ATPase and the Na(+)/Ca(2+) Exchanger are antithetically regulated during mouse cardiac development and in Hypo/hyperthyroidism. J. Mol. Cell Cardiol. 32(3): 453-464, 2000. 2. Magee, W.P., Deshmukh, G., Deninno, M.P., Sutt, J.C., Chapman, J.G., Tracey, W.R: Differing cardioprotective efficacy of the Na+/Ca2+ exchanger inhibitors SEA0400 and KB-R7943. Am. J. Physiol. Heart Circ. Physiol. 284(3): 903-910 (2003, Mar).

Additional Info

Reacts with the Na(+)/Ca(2+)- exchanger in a number of species and tissues.

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