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NDE1, NT (Nuclear Distribution Protein nudE Homolog 1, NUDE1, NUDE, FLJ20101, HOM-TES-87) (FITC)

Cat no: N0570-25N-FITC

NDE1, NT (Nuclear Distribution Protein nudE Homolog 1, NUDE1, NUDE, FLJ20101, HOM-TES-87) (FITC)

NDE1 is required for centrosome duplication. It is essential for the development of the cerebral cortex. It may regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex (By similarity). This protein is required for formation and function of the mitotic spindle.\n\nApplications: \nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-1:500\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze FITC conjugates. Light sensitive. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

N0570-25N-FITC

Size

200ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to FITC.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Mayya V., et.al., Sci. Signal. 2:RA46-RA46(2009).

Additional Info

Recognizes human NDE1.

Alternative Names

NudE Nuclear Distribution Gene E Homolog 1 (A. nidulans)

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