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Neurocan pAb

Neurocan pAb

Cat no: BS5819

Supplier: Bioworld Technology, Inc.
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The lecticans are a family of chondroitin proteoglycans, including aggrecan, versican, neurocan and brevican, that contain a C-type lectin domain. Neurocan is a glycoprotein synthesized primarily by neurons, and its expression levels are highest during embryonic brain development and during the early postnatal period. Neurocan is a component of the extracellular matrix in the central nervous system that can bind to various other CNS matrix components, such as heparin, Tenascin-R, HB-GAM and NCAM, suggesting that it plays a role in axon guidance and neurite growth. Neurocan is a 1,257 amino acid, precursor protein in embryonic and neonatal rats that is proteolytically proc-essed in the adult CNS into an N-terminal fragment, which localizes to the cytoplasm of glial cells. Neurocan expression (including the re-expression of the neonatal isoform) increases significantly in adults in the glial scar resulting from cortical injury.
Catalogue number: BS5819
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug/100ul
Swiss prot: O14594
Dilutions: WB: 1:500~1:1000
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 440-485 of Human Neurocan.
Species: Neurocan pAb detects endogenous levels of Neurocan protein.
Molecular weight: ~ 220 kDa (Full length), 140 kDa (Proteolytic variant)
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Neurocan core protein; Chondroitin sulfate proteoglycan 3; NCAN; CSPG3; NEUR
Additional info: For research use only, not for use in diagnostic procedure.

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