Neurofibromin (R1575) pAb

Cat no: BS2687

Supplier: Bioworld Technology, Inc.

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Additional Information

Neurofibromatosis type 1 (NF1), or von Reckinghausen neurofibromatosis, is one of the most common autosomal dominant disorders in humans. Early linkage analysis mapped the NF1 gene to chromosome 17. The predicted NF1 transcript encodes a 2818 amino acid protein designated NF1GRP. By sequence analysis, similarity has been demonstrated within a small region of NF1GRP and members of the Ras GAP gene family. Functionally, NF1GRP was shown by biochemical analysis involving RAS-GAP hydrolysis and functional complementation in yeast to further resemble GAP protein. The NF1 protein is expressed at relatively constant levels in a broad range of cell lines and tissues including brain, lung, liver, kidney, spleen, muscle and colon.Although little is known regarding the function of NF1GRP, the homology with the catalytic domain of proteins with GTPase activity suggests that the NF1GRP may also interact in vivo with Ras proteins.

Catalogue number:	BS2687
Reactivities:	Human, Mouse, Rat
Hosts:	Rabbit
Applications:	Immunofluorescence, Western Blot
Size:	100ug/100ul
Swiss prot:	P21359
Dilutions:	WB: 1:500~1:1000 IF: 1:50~1:200
Form:	liquid
Storage buffer:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration:	1ug/ul
Antigen:	Synthetic peptide, corresponding to amino acids 1550-1600 of Human Neurofibromin.
Species:	Neurofibromin (R1575) pAb detects endogenous levels of Neurofibromin protein.
Molecular weight:	~ 319 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp:	Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names:	Neurofibromin; Neurofibromatosis-related protein NF-1; Neurofibromin; 4763; NF1; 162200; P21359; DKFZp686J1293; NFNS; VRNF; WSS;
Additional info:	For research use only, not for use in diagnostic procedure.

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Neurofibromin (R1575) pAb

Cat no: BS2687

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