NF-1 (Q34) Peptide

NF-1, also designated CTF, consists of a family of CCAAT-box-binding proteins that stimulate DNA replication and activate transcription. Analysis of human NF-1 messenger RNA has revealed two forms of the NF-1 protein arising from an alternate splicing of a single NF-1 gene. NF-1 binds its consensus DNA element as a homodimer via an amino-terminal DNA-binding domain, and activates transcription through a putatively novel, proline-rich, carboxy-terminal transactivation domain. The NF-1 protein has been shown to recognize and bind the adenovirus type 2 promoter and activate transcription of herpes simplex virus thymidine kinase genes. The NF-1 consensus element has been found in the upstream promoter region of myriad eukaryotic genes, including that of Ha-Ras, alpha-globin, HSP 70, GRP 78, Histone H1,myelin basic protein and in the Xenopus laevis vitellogenin gene promoter.

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SPECIFICATIONS

Catalog Number

BS2042P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide NF-1 (Q34). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

Q12857/O00712/P08651/Q14938

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS2042 NF-1 (Q34) pAb.

Alternative Names

NF1A; Nuclear factor 1/X; NF1-X; NFI-X; NF-I/X; CCAAT-box-binding transcription factor; CTF; TGGCA-binding protein; NF1A; nuclear factor I/X (CCAAT-binding transcription factor)