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NHE3 (Na, H Exchanger 3)

Cat no: N2017

NHE3 (Na, H Exchanger 3)

Na+/H+ exchangers (NHE) of mammalian cells are plasma membrane intrinsic proteins mediating exchange of Na+ and H+ ions in various tissues. The NHE catalyzes the electoneuronal transport of extracellular Na+ for intracellular H+. They play a major role in regulation of intracellular pH (pHi) addition to trans-cellular absorption of Na+, cell volume regulation and possibly in cell proliferation. These primary functions of the Na+/H+ exchanger have been related to many pathophysiological states, include hypertension, organ growth and hypertrophy, regression of cancer and renal intestinal disorders. Five isoforms (NHE3-5) have been cloned so far. They are all similar in their primary structure and predicted to have 10

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SPECIFICATIONS

Catalog Number

N2017

Size

50ug

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Rat

Form

Supplied as a liquid in PBS, pH 7.4 and 0.1% BSA and 0.05% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Brant SR et al (1995) Am. J. Physiol. 269: C198-C206; Orlowsji J et al (1992) J Biol Chem 267: 9331; Chris Yun CH et al (1995) Am J Physiol. 269: G1-G11 (review); Josette N and Pouyssegur J \n(1995) Am J Physiol. 268: C283-C296 (review). 2. Yoshioka et al (1997) J Biochem. (Tokyo) 122: 641-646.

Additional Info

Recognizes rat NHE3. Species Sequence Homology: Mouse: 90%; Human: 76%.

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