NIPA (S350) Peptide

Entry into mitosis is essentially driven by cyclin B1 which is located in the cytoplasm throughout interphase, but accumulates in the nucleus just before mitosis occurs. Nuclear Interaction Partner of ALK (NIPA) plays a critical role in cyclin B1 regulation. NIPA is normally phosphorylated during G2 and M phases, resulting in an accumulation of cyclin B1. When NIPA sheds its attached phosphate, it binds to SCF to form the SCFNIPA complex, a member of the E3 ubiquitin ligases, which ubiquitinates cyclin B1, thereby targeting it to the proteosome for degradation.

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SPECIFICATIONS

Catalog Number

BS1847P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide NIPA (S350). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

Q86WB0

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS1847 NIPA (S350) pAb.

Alternative Names

Nuclear-interacting partner of ALK; Nuclear-interacting partner of anaplastic lymphoma kinase; hNIPA; Zinc finger C3HC-type protein 1; HSPC216; NIPA; ZC3HC1