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Nkx-2.6 (R133) Peptide

Nkx-2.6 (R133) Peptide

Cat no: BS3317P

Supplier: Bioworld Technology, Inc.
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Members of the NK-2 family of homeodomain proteins are key regulators of growth and development in several tissues, including brain, heart and pancreas.Nkx-2.5, also designated cardiac specific homeobox protein (Csx), is a homolog of the Drosophila tinman protein and is essential for normal cardiovascular development. Expression of Nkx-2.5 during cardiomyogenesis is required for cardiac septation, in which a single atrium and ventricle are separated into four chambers. Nkx-2.5 binds to DNA as a monomer, a homodimer or as a heterodimer with Nkx-2.3 or Nkx-2.6, which suggests that the specific protein-protein interactions of Nkx-2.5 are involved in its transcriptional regulatory function. Nkx-2.6, also a homolog of the Drosophila tinman protein, is expressed in the caudal pharyngeal pouches,the caudal heart progenitors, the sinus venosus, the outflow tract of the heart and in a short segment of the gut between stages E8.5 and E10.5 of embryogenesis. Expression of Nkx-2.6 overlaps with that of Nkx-2.5 in the pharynx and heart. However, Nkx-2.6 mutant mice are viable and fertile, which suggests that Nkx-2.6 plays a compensatory function to Nkx-2.5.
Catalogue number: BS3317P
Applications: Block/Neutralize/Inhibit
Swiss prot: A6NCS4
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide Nkx-2.6 (R133). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: NKX2F; NKX2-6; Homeobox protein NK-2 homolog F; Homeobox protein Nkx-2.6
Additional info: This peptide can be used with studies using BS3317 Nkx-2.6 (R133) pAb.

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