Nkx-3.1 (L2) Peptide

Cat no: BS1456P

Supplier: Bioworld Technology, Inc.

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Description
Additional Information

The homeobox gene Nkx-3.1 is the human homolog of Drosophila bagpipe, which, in conjunction with tinman, determines cell fate in the dorsal mesoderm. In mammalian species, Nkx-3.1 is predominantly expressed in prostate, and it regulates prostate development in response to sonic hedgehog (Shh) signaling by exerting growth-suppressive and differentiating effects on prostatic epithelium. Nkx-3.1 is also expressed at lower levels in other tissues, including the heart and gut, in a Shh independent manner, where it plays a role in regulating proliferation of glandular epithelium and in the formation of ducts in prostate and minor salivary glands. Nkx-3.1 preferentially binds the TAAGTA sequence, which has not been reported for any other NK class homeoprotein. The human Nkx-3.1 gene is located on chromosome 8q21, which frequently undergoes a loss of heterozygosity, and although Nkx-3.1 is not a tumor suppressor gene, it may be a useful marker for benign and malignant prostate epithelium.

Catalogue number:	BS1456P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	Q99801
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide Nkx-3.1 (L2). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	NKX3-1; NKX3.1; NKX3A
Additional info:	This peptide can be used with studies using BS1456 Nkx-3.1 (L2) pAb.

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Nkx-3.1 (L2) Peptide

Cat no: BS1456P

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