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NMDA 2b Receptor (NT) (NMDA R2b, N-methyl-D-aspartate, GRIN2B, Glutamate receptor ionotropic N-methyl D-aspartate 2B, HGNC:4586, NR2B, hNR3, N-methyl-D-aspartate receptor subunit 2B)

Cat no: N2905-30A

NMDA 2b Receptor (NT) (NMDA R2b, N-methyl-D-aspartate, GRIN2B, Glutamate receptor ionotropic N-methyl D-aspartate 2B, HGNC:4586, NR2B, hNR3, N-methyl-D-aspartate receptor subunit 2B)

Receptors for NMDA belong to a group of ionotropic glutamate receptors which play a key role in the mediation of glutamate neurotransmission within the mammalian central nervous system (CNS), including involvement in memory and learning processes. Several antagonists and agonists of NMDA receptors (NMDAR) have been identified. Properties of NMDAR include modulation by glycine, inhibition by Zn2+, voltage-dependent Mg2+ blockade and high Ca2+permeability. The involvement of NMDAR in the CNS has become a focus area for neurodegenerative diseases such as Alzheimer

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SPECIFICATIONS

Catalog Number

N2905-30A

Size

100ul

Applications

WB

Hosts

Rabbit

Reactivities

Rat

Form

Supplied as a liquid in10mM HEPES, pH 7.5, 150mM sodium chloride, 0.01% BSA, 50% glycerol.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Chung, H.J. et al. (2004) Regulation of the NMDA receptor complex and trafficking by activity-dependent phosphorylation of the NR2B subunit PDZ ligand. J. Neurosci. 24: 10248-10259. 2. Popke, E.J. (2003) TOXOLOGICAL HIGHLIGHT: From anticholinesterase toxicity to Alzheimer's disease: Important interactions of cholinergic and NMDA receptor systems. Toxological Sciences 72: 185-187.

Additional Info

Recognizes the NR2B subunit of the rat NMDA (N-methyl-D-aspartate) receptor at ~180kD. Species sequence homology: Mouse, Dog, Primate, Human, Bovine, Chicken.

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