NRF1, ID (NRF1, Nuclear respiratory factor 1, Alpha palindromic-binding protein) (APC)

This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for 'nuclear factor (erythroid-derived 2)-like 1' which has an official symbol of NFE2L1.\n\nApplications:\nSuitable for use in Western Blot, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze APC conjugates. Light sensitive. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

039144-APC

Size

200ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to Allophycocyanin (APC).

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Gonen, N., et al. J. Biol. Chem. 285(44):33602-33613(2010)\nZhang, Y., et al. Biochem. J. 430(3):497-510(2010)\nShao, D., et al. Mitochondrion 10(5):516-527(2010)\nAdam, T., et al. Biochem. Biophys. Res. Commun. 398(3):495-499(2010)\nSpelbrink, J.N., et al. Hum. Mol. Genet. 4(9):1591-1596(1995)

Additional Info

Human

Alternative Names

NRF1, Nuclear respiratory factor 1, Alpha palindromic-binding protein