NRG1 pAb

Neuregulin-1 gene, NRG1, encodes numerous splice variants with differing transcription initiation sites. Neuregulin-1 includes a range of isoforms with varying glycosylation, regulation of expression and function. Neuregulin-1 splice variants each bear an EGF-like domain, though otherwise have unique domain structures, differing functions and discrete tissue distribution. Six types of Neuregulin-1 isoform groups have been defined based on their structural features. Three types are most often described, type I (ARIA, NDF or HRG), type II (GGF) and type III (SMDF). Neuregulin-1 has been linked to schizophrenia and has diverse neural functions. Neuregulin-1 affects cell migration, the differentiation of neural crest and Schwann cells, and acts to upregulate the expression of acetylcholine receptors at muscle fibers during the formation of neuromuscular junctions.

Prices direct from Bioworld Technology, Inc.

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

BS6037

Size

100ug/100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Recombinant full length Human NRG1.

Species

NRG1 pAb detects endogenous levels of NRG1 protein.

Dilutions

WB: 1:500~1:2000\nIHC: 1:50~1:200

Swiss Prot

Q02297

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 30,50,70 kDa

Alternative Names

Acetylcholine receptor inducing activity; \nAcetylcholine receptor-inducing activity; \nARIA; \nBreast cancer cell differentiation factor p45; \nERBB2 p185 activator; \nGGF 2; \nGGF; \nGGF2; \nGlial growth factor; \nHeregulin alpha; \nHeregulin; \nheregulin; alpha (45; ERBB2 p185-activator); \nHGL; \nHRG 1; \nHRG; \nHRG1; \nHRGA; \nMST131; \nNDF; \nNeu differentiation factor; \nNeuregulin 1; \nneuregulin 1 type IV beta 1a; \nneuregulin 1 type IV beta 3; \nNeuregulin-1; \nNeuregulin1; \nNRG 1; \nnrg1; \nNRG1; \nOTTHU