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NSD1 / KMT3B mAb

NSD1 / KMT3B mAb

Cat no: MB0059

Supplier: Bioworld Technology, Inc.
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This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene.
Catalogue number: MB0059
Reactivities: Human
Hosts: Mouse
Applications: Western Blot
Size: 100ug/100ul
Swiss prot: Q96L73
Dilutions: WB: 1:1000
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Recombinant full length Human NSD1 / KMT3B.
Species: This antibody detects endogenous levels of NSD1 / KMT3B and does not cross-react with related proteins
Molecular weight: Predicted band size:297KDa Observed band size:300KDa
Purity: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: STO; KMT3B; SOTOS; ARA267; FLJ10684; FLJ22263; FLJ44628; DKFZp666C163; H3-K36-HMTase; H4-K20-HMTas
Additional info: For research use only, not for use in diagnostic procedure.

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