NTR1 (H218) Peptide

Cat no: BS2820P

Supplier: Bioworld Technology, Inc.

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Neurotensin (NT) initiates an intracellular response by interacting with the G protein-coupled receptors NTR1 (NTS1 receptor, high affinity NTR) and NTR2 (NTS2 receptor, levocabastine-sensitive neurotensin receptor), and the type I receptor NTR3 (NTS3 receptor, sortilin-1, Gp95). NT has a wide distribution in regions of the brain and in peripheral tissues where NT receptors can contribute to hypotension, hyperglycemia, hypothermia, antinociception and regulation of intestinal motility and secretion. HL-60 cells express NTR1, which can couple to Gq, Gi/o, or Gs. Alternative splicing of rat NTR2 can generate a 5-transmembrane domain variant isoform that is co-expressed with the full-length NTR2 throughout the brain and spinal cord. NTR3 activation in the murine microglial cell line N11 induces MIP-2, MCP-1, IL-1beta and TNFalpha in an ERK1/2 and Akt kinase-dependent manner.

Catalogue number:	BS2820P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	P30989
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide NTR1 (H218). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	NTSR1; NT-R-1; NTR; NTRH; NTRR
Additional info:	This peptide can be used with studies using BS2820 NTR1 (H218) pAb.

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NTR1 (H218) Peptide

Cat no: BS2820P

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