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NU6102 (O6-Cyclohexylmethyl-2-(4-sulfamoylanilino)purine)

Cat no: 045108


Supplier: United States Biological
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Potent CDK1/cyclin B (IC50 = 9.5 nM) and CDK2/cyclin A3 (IC50 = 5.4 nM) inhibitor. 1'000-fold more potent than NU2058. Selective for CDK1 and CDK2 compared to CDK4/D1 (IC50 = 1.6 microM), DYRK1A (IC50 = 0.9 microM), PDK1 (IC50 = 0.8 microM) and ROCKII (IC50 = 0.6 microM). Inhibits cell growth. Storage and Stability: Short-term Storage: +4 degrees C Long-term Storage: -20 degrees C Stable for at least 2 years after receipt when stored at -20 degrees C.
Catalogue number: 045108
Size: 1mg
Purity: >98% (NMR)
Alternative names: O6-Cyclohexylmethyl-2-(4-sulfamoylanilino)purine
References: Product Reference: ?Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor: T.G. Davies, et al.; Nat. Struct. Biol. 9, 745 (2002) ?N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2: I.R. Hardcastle, et al.; J. Med. Chem.47, 3710 (2004) ?Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2: K.L. Sayle, et al.; Bioorg. Med. Chem. Lett. 13, 3079 (2003) ?

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