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OPG (P25) Peptide

OPG (P25) Peptide

Cat no: BS1862P

Supplier: Bioworld Technology, Inc.
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The cytokine osteoprotegerin(OPG), also designated osteoclastogenesis inhibitory factor (OCIF), is known to inhibit osteoclast formation. A secreted glycoprotein, OPG is a member of the TNF receptor family that increases bone density and volume. OPG is thought to inhibit osteoclastogenesis by disrupting the cell-to-cell signaling between osteoblastic stromal cells and osteoclast progenitors. OPG is known to bind to TRAIL, a death domain-containing protein, and to inhibit TRAIL apoptosis in Jurkat cells. OPG also binds to osteoclast differentiation factor (ODF), also known as TRANCE/RANKL, a membrane-bound protein belonging to the TNF ligand family. Both TNFalpha and TNFbeta upregulate OPG expression, while the bone resorbing agent prostaglandin E2 downregulates OPG.
Catalogue number: BS1862P
Applications: Block/Neutralize/Inhibit
Swiss prot: O00300
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide OPG (P25). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: Tumor necrosis factor receptor superfamily member 11B; Osteoclastogenesis inhibitory factor; Osteoprotegerin; TNFRSF11B; OCIF; OPG
Additional info: This peptide can be used with studies using BS1862 OPG (P25) pAb.

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