Orexin Receptor Type 2 (HCRTR2, Ox-2-R, Ox2-R, Ox2R, Hypocretin Receptor Type 2)

Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides.\n\nApplications:\nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:32,000\nWestern Blot: 1-3ug/ml, observed in human brain (cerebral cortex, hippocampus and substantia nigra) lysates on ~50kD bands\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

O7505-11V

Size

100ug

Applications

ELISA, WB

Hosts

Goat

Reactivities

Hum, Bov, Can, Prc

Form

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

References

1. Spinazzi R, Rucinski M, Neri G, Malendowicz LK, Nussdorfer GG. Preproorexin and orexin receptors are expressed in cortisol-secreting adrenocortical adenomas, and orexins stimulate in vitro cortisol secretion and growth of tumor cells. J Clin Endocrinol Metab. 2005 Jun;90(6):3544-9. Epub 2005 Mar 29.

Additional Info

Recognizes human HCRTR2. Species sequence homology: Bovine, canine and porcine.