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p-ABL1 (Y204) Peptide

Cat no: BS4465P

p-ABL1 (Y204) Peptide

The Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). The major translational product of c-Abl has been identified as a protein with tyrosine kinase activity and an SH2 domain. The Abl oncogene is implicated in several human leukemias including 90-95% of chronic myelocytic leukemia (CML), 20-25% of adult acute lymphoblastic leukemia (ALL) and 2-5% of pediatric ALL. In these leukemias the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation producing the Philadelphia (Ph1) chromosome. The molecular consequence of this translocation is the generation of a chimeric Bcr/c-Abl mRNA encoding activated Abl protein-tyrosine kinase. The Bcr gene has been shown to encode a GTPase-activating protein (GAP) specific for the Ras-related GTP-binding protein, p21rac.

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SPECIFICATIONS

Catalog Number

BS4465P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide p-ABL1 (Y204). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

P00519

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS4465 p-ABL1 (Y204) pAb.

Alternative Names

ABL1; ABL; JTK7; p150; Proto-oncogene c-Abl; Tyrosine-protein kinase ABL1; c-Abl

SUPPLIER INFO

Bioworld Technology, Inc.

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