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p-ACC(alpha) (S80) pAb

p-ACC(alpha) (S80) pAb

Cat no: BS4210

Supplier: Bioworld Technology, Inc.
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Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the ratelimiting step in fatty acid synthesis. Exercise diminishes the activity of acetyl- CoA carboxylase in human muscle. ACC(alpha) (ACC1) is the rate-limiting enzyme in the biogenesis of long-chain fatty acids, and ACC(beta) (ACC2) may control mitochondrial fatty acid oxidation. These two isoforms of ACC control the amount of fatty acids in the cells. The catalytic function of ACC(alpha) is regulated by phosphorylation (inactive) and dephosphorylation (active) of targeted Serine residues and by allosteric transformation by citrate or palmitoyl-CoA, which serve as the short-term regulatory mechanism of the enzyme. The gene encoding ACC(alpha), which maps to human chromosome 17, encodes the 265 kDa (alpha) form of ACC, which is the major ACC in lipogenic tissues. The catalytic core of ACC(beta) is homologous to that of ACC(alpha) except for an additional peptide of about 150 amino acids at the N-terminus.
Catalogue number: BS4210
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: Q13085
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic phosphopeptide derived from human ACC(alpha) around the phosphorylation site of Serine 80.
Species: p-ACC(alpha) (S80) pAb etects endogenous levels of ACC(alpha) protein only when phosphorylated at Ser80.
Molecular weight: ~ 265 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Acetyl-CoA carboxylase 1; Short name=ACC1; ACC-alpha; Biotin carboxylase; ACACA; ACAC; ACC1; ACCA
Additional info: For research use only, not for use in diagnostic procedure.

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