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p-APP/(beta)-Amyloid (T668) pAb

p-APP/(beta)-Amyloid (T668) pAb

Cat no: BS4214

Supplier: Bioworld Technology, Inc.
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Proteolytic cleavage of the Amyloid protein precursor (APP) gives rise to the (beta)-Amyloid and Amyloid A4 proteins, which are present in human platelets. Amyloid deposition is associated with type II diabetes, Down syndrome and a variety of neurological disorders, including Alzheimer's disease. The Amyloid precursor protein (APP) undergoes alternative splicing, resulting in several isoforms. Proteolytic cleavage of APP leads to the formation of the Amyloid (beta)/A4 Amyloid protein. This protein is involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer's patients. APLP1 (Amyloid precursor-like protein 1) and APLP2 are structurally similar to APP.
Catalogue number: BS4214
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P05067
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic phosphopeptide derived from human APP/(beta)-Amyloid around the phosphorylation site of Threonine 668.
Species: p-APP/(beta)-Amyloid (T668) pAb detects endogenous levels of APP695 protein only when phosphorylated at Thr668 (or the corresponding position on other isoforms).
Molecular weight: ~ 70 to140 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Amyloid beta A4 protein; ABPP; APPI; Short name=APP; Alzheimer disease amyloid protein; Cerebral vascular amyloid peptide; Short name=CVAP; PreA4; Protease nexin-II; Short name=PN-II; N-APP; Soluble APP-alpha; Short name=S-APP-alpha; Soluble APP-beta; Short name=S-APP-beta; Beta-amyloid protein 42; Beta-APP42; Beta-amyloid protein 40; Beta-APP40; P3(42); P3(40); Gamma-secretase C-terminal fragment 59; Amyloid intracellular domain 59; Short name=AICD-59; Short name=AID(59); Gamma-CTF(59); Gamma-secretase C-terminal fragment 57; Amyloid intracellular domain 57; Short name=AICD-57; Short name=AID(57); Gamma-CTF(57); Gamma-secretase C-terminal fragment 50; Amyloid intracellular domain 50; AICD-50; AID(50); Gamma-CTF(50); APP; A4; AD; Amyloid-(beta); Amyloid (beta); Amyloid(beta); (beta) Amyloid; (beta)Amyloid; A(beta)
Additional info: For research use only, not for use in diagnostic procedure.

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