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p-Bcr (Y177) Peptide

p-Bcr (Y177) Peptide

Cat no: BS4026P

Supplier: Bioworld Technology, Inc.
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The Bcr gene, mapping on chromosome 22, was initially identified on the basis of its fusion with the c-Abl proto-oncogene on chromosome 9 resulting in the generation of the Philadelphia chromosome in 90-95% of patients with chronic myelogenous leukemia (CML). The Bcr gene encodes for the Breakpoint cluster region protein (Bcr). A consequence of this translocation is the generation of a Bcr/c-Abl mRNA encoding an activated c-Abl protein kinase. The Bcr gene has been shown to encode a 160 kDa GTPase-activating protein (GAP) specific for the Ras-related GTP-binding protein, Rac 1 p21. While it has been speculated that the Bcr protein may also stimulate Rac 2 p21 GTPase activity, it has no effect on Ras p21 or Rho p21 GTPases.
Catalogue number: BS4026P
Applications: Block/Neutralize/Inhibit
Swiss prot: P11274
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide p-Bcr (Y177). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: Breakpoint cluster region protein; Renal carcinoma antigen NY-REN-26; BCR; BCR1; D22S11
Additional info: This peptide can be used with studies using BS4026 p-Bcr (Y177) pAb.

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