p-BIK/ NBK (T33) pAb

Cat no: BS4215

Supplier: Bioworld Technology, Inc.

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The Bcl-2 gene was isolated at the chromosomal breakpoint of t-bearing follicular B cell lymphomas. Bcl-2 blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal. A protein designated Bax p21 (i.e., Bcl-associated X protein) has extensive amino acid homology with Bcl-2 and both homodimerizes and heterodimerizes with Bcl-2. Overexpression of Bax accelerates apoptotic death. Natural born killer (NBK), also known as Bik, is a protein that is functionally related to Bax, although the two proteins share very little sequence homology. NBK does not contain the conserved Bcl-2 homology domains (BH domains) characteristic of the Bcl-2 family. It does however, share nine amino acids with Bax in a region designated BH3, which may be the critical determinant for the protein's death-promoting activities. Phosphorylation of NBK at Ser35 and Thr33 is required for eliciting efficient apoptotic activity.

Catalogue number:	BS4215
Reactivities:	Human
Hosts:	Rabbit
Applications:	Immunohistochemistry, Western Blot
Size:	100ug/100ul
Swiss prot:	Q13323
Dilutions:	WB: 1:500~1:1000 IHC: 1:50~1:200
Form:	liquid
Storage buffer:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration:	1ug/ul
Antigen:	Synthetic phosphopeptide derived from human BIK/ NBK around the phosphorylation site of Threonine 33.
Species:	p-NBK (T33) pAb detects endogenous levels of NBK protein only when phosphorylated at Thr33.
Molecular weight:	~ 23 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp:	Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names:	Apoptosis inducer NBK; BBC1; Bcl-2-interacting killer; BCL2 interacting killer; bhikhari; BIK; Bik-like killer protein; BIK; BIP 1; BIP1; BP 4; BP4; cb 60; NBK;
Additional info:	For research use only, not for use in diagnostic procedure.

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p-BIK/ NBK (T33) pAb

Cat no: BS4215

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