p-BRCA1 (S1423) Peptide

Cat no: BS4756P

Supplier: Bioworld Technology, Inc.

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Additional Information

BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. It combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC (for BRCA1 associated genome surveillance complex). BRCA1 associates with RNA polymerase II, and through the C terminal domain, also interacts with histone deacetylase complex. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in the BRCA1 gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.

Catalogue number:	BS4756P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	P38398
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide p-BRCA1 (S1423). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	Breast cancer type 1 susceptibility protein; RING finger protein 53; BRCA1; RNF53
Additional info:	This peptide can be used with studies using BS4756 p-BRCA1 (S1423) pAb.

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p-BRCA1 (S1423) Peptide

Cat no: BS4756P

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