p-c-Rel (S503) Peptide

Cat no: BS4839P

Supplier: Bioworld Technology, Inc.

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c-Rel is the cellular cognate of v-Rel, the avian reticuloendotheliosis virus strain T transforming gene. v-Rel encodes a phosphoprotein that is located in the cytoplasm of transformed spleen cells and in the nucleus of non-transformed fibroblasts, in contrast to the c-Rel protein, which is cytoplasmic. c-Rel has been shown to represent a constituent of the kB site binding transcription factor NFkB, which plays a crucial role in the expression of immunoglobulin k light chain gene. In contrast to c-Rel, v-Rel is truncated in its C-terminal transactivation domain and does not appear to function as a transcriptional transactivator. It has thus been postulated that v-Rel may interfere with the normal transcription of NFkB regulated genes and thus cause transformation by a mechanism analogous to v-ErbA, which binds to the thyroid hormoneresponsive region in certain erythroid genes needed for differentiation, but cannot be activated by thyroid hormone.

Catalogue number:	BS4839P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	Q04864
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide p-c-Rel (S503). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	C REL; C Rel protein; c Rel proto oncogene protein; Oncogene REL; Oncogene REL avian reticuloendotheliosis; Proto-oncogene c-Rel; REL;
Additional info:	This peptide can be used with studies using BS4839 p-c-Rel (S503) pAb.

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p-c-Rel (S503) Peptide

Cat no: BS4839P

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