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p-Catenin-(beta) (T41/S45) pAb

p-Catenin-(beta) (T41/S45) pAb

Cat no: BS4030

Supplier: Bioworld Technology, Inc.
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(beta)-Catenin is a key downstream effector in the Wnt signaling pathway. It is implicated in two major biological processes in vertebrates: early embryonic development and tumorigenesis. CK1 phosphorylates (beta)-catenin at Ser45. This phosphorylation event primes (beta)-catenin for subsequent phosphorylation by GSK-3(beta). GSK-3(beta) destabilizes (beta)-catenin by phosphorylating it at Ser33, Ser37, and Thr41. Mutations at these sites result in the stabilization of (beta)-catenin protein levels and have been found in many tumor cell lines.
Catalogue number: BS4030
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug/100ul
Swiss prot: P35222
Dilutions: WB: 1:500~1:1000
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: A phospho specific peptide corresponding to residues surrounding threonine 41 and 45 of Human Catenin-(beta).
Species: p-Catenin-(beta) (T41+S45) pAb detects endogenous levels of Catenin-(beta) protein only when phosphorylated at Thr41+S45 .
Molecular weight: ~ 92 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Catenin (beta); Catenin(beta); Catenin beta-1; Beta-catenin; CTNNB1; CTNNB; ORF Names: OK/SW-cl.35; PRO2286
Additional info: For research use only, not for use in diagnostic procedure.

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