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p-CD28 (Y218) Peptide

p-CD28 (Y218) Peptide

Cat no: BS4665P

Supplier: Bioworld Technology, Inc.
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T cell proliferation and lymphokine production are triggered by occupation of the TCR by antigen, followed by a costimulatory signal that is delivered by a ligand expressed on antigen presenting cells. The B7-related cell surface proteins CD80 (B7-1) and CD86 (B7-2) are expressed on antigen presenting cells, bind the homologous T cell receptors CD28 and CTLA-4 (cytotoxic T lymphocyte-associated protein-4) and trigger costimulatory signals for optimal T cell activation. CTLA-4 shares 31% overall amino acid identity with CD28, and it has been proposed that CD28 and CTLA-4 are functionally redundant. SLAM is a novel receptor on T cells that, when engaged, potentiates T cell expansion in a CD28-independent manner. B7, also designated BB1, is another ligand or counterreceptor for CD28 and CTLA-4 that is expressed on the antigen-presenting cell.
Catalogue number: BS4665P
Applications: Block/Neutralize/Inhibit
Swiss prot: P10747
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide p-CD28 (Y218). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: T-cell-specific surface glycoprotein CD28; TP44
Additional info: This peptide can be used with studies using BS4665 p-CD28 (Y218) pAb.

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