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p-Chk2 (T68) Peptide

Cat no: BS4043P

p-Chk2 (T68) Peptide

Cell cycle events are regulated by the sequential activation and deactivation of cyclin dependent kinases (Cdks) and by proteolysis of cyclins. Chk1 and Chk2 are involved in these processes as regulators of Cdks. Chk1 and Chk2 both function as essential components in the G2 DNA damage checkpoint by phosphorylating Cdc25C in response to DNA damage. Phosphorylation inhibits Cdc25C activity, thereby blocking mitosis. Cdc25A, Cdc25B and Cdc25C protein tyrosine phosphatases function as mitotic activators by dephosphorylating Cdc2 p34 on regulatory tyrosine residues. It has also been shown that Chk1 can phosphorylate Wee1 in vitro, providing evidence that the hyperphosphorylated form of Wee1, seen in cells delayed by Chk1 overexpression, is due to phosphorylation by Chk1..

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SPECIFICATIONS

Catalog Number

BS4043P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide p-Chk2 (T68). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

O96017

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS4043 p-Chk2 (T68) pAb.

Alternative Names

Serine/threonine-protein kinase Chk2; CHK2 checkpoint homolog; Cds1 homolog; Hucds1; hCds1; Checkpoint kinase 2; CHEK2; CDS1; CHK2; RAD53

SUPPLIER INFO

Bioworld Technology, Inc.

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