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p-Cortactin (Y421) Peptide

p-Cortactin (Y421) Peptide

Cat no: BS4778P

Supplier: Bioworld Technology, Inc.
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Cortactin is an 80/85 kDa cytoskeleton protein that facilitates assembly of cortical actin. Cortactin is widely expressed in most adherent cells and is a prominent substrate of protein tyrosine kinase Src in vivo and in vitro. The protein sequence of cortactin contains multiple amino terminal tandem repeats of a unique 37 amino acid sequence, which associates with actin, and a Src homology 3 (SH3) domain at the carboxyl terminus. Between the repeat and the SH3 domain, there is an alpha helical structure followed by a proline rich region. Between the proline rich region and the SH3 domain, there are a series of Src phosphorylation sites (Tyr421, Tyr470, and Tyr486). In vitro, cortactin binds to and cross links F actin into meshworks.
Catalogue number: BS4778P
Applications: Block/Neutralize/Inhibit
Swiss prot: Q14247
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide p-Cortactin (Y421). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: Src substrate cortactin; Amplaxin; Oncogene EMS1; CTTN; EMS1
Additional info: This peptide can be used with studies using BS4778 p-Cortactin (Y421) pAb.

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