p-Cot (T290) Peptide

Cat no: BS4051P

Supplier: Bioworld Technology, Inc.

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The role of mitogen-activated protein kinases (MAPKs) in cell signaling pathways is well established. The rat gene Tpl-2, for tumor progression locus 2, and the human and mouse homologues c-Cot, for cancer osaka thyroid oncogene, encode a proto-oncogene serine/threonine protein kinase that was shown to play a role in the functional activation of the MAP kinase pathway. Overexpression of Cot induces MAP kinase activation in COS-1 and NIH/3T3 cells. Cot-mediated activation of MAP kinase is inhibited by both Ras N17, a dominant negative mutant of c-H-Ras, and Raf-1s621A, a dominant negative mutant of Raf-1, suggesting that Cot functions upstream of Ras and Raf-1.Other studies have shown that a kinase-negative, dominant negative mutant of Cot partially blocks Ras or Raf-1-induced MAP kinase activation, arguing that Cot functions downstream of Ras and Raf-1.

Catalogue number:	BS4051P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	P41279
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide p-Cot (T290). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	CCOT; COT; COT proto oncogene serine/threonine protein kinase; EST; ESTF; Ewing sarcoma transformant; FLJ10486; M3K8; MAP3K 8; MAP3K8; TPL 2; TPL-2; TPL2; Tumor progression locus 2;
Additional info:	This peptide can be used with studies using BS4051 p-Cot (T290) pAb.

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p-Cot (T290) Peptide

Cat no: BS4051P

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