p-Crk2 (Y221) pAb

Cat no: BS4055

Supplier: Bioworld Technology, Inc.

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Description
Additional Information

Crk I and Crk II are encoded by the same gene, which undergoes alternative splicing to yield these two proteins, but differ in their biological activities. Crk II has less transforming activity than Crk I, although both Crk I and Crk II bind to many tyrosine-phosphorylated proteins that bind to GRB2. In addition, Crk II becomes rapidly tyrosine-phosphorylated in response to stimulation with insulin-like growth factor I (IGF-I) and might be involved in the IGF-I receptor signalling pathway.

Catalogue number:	BS4055
Reactivities:	Human, Mouse, Rat
Hosts:	Rabbit
Applications:	Western Blot
Size:	100ug/100ul
Swiss prot:	P46108
Dilutions:	WB: 1:500~1:1000
Form:	liquid
Storage buffer:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration:	1ug/ul
Antigen:	Synthetic phosphopeptide derived from human Crk2 around the phosphorylation site of Tyrosine 221.
Species:	p-Crk II (Y221) pAb detects endogenous levels of Crk II protein only when phosphorylated at Tyr221.
Molecular weight:	~ 42 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp:	Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names:	Adapter molecule crk; Proto-oncogene c-Crk; p38 CRK; CRK; CRKII
Additional info:	For research use only, not for use in diagnostic procedure.

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p-Crk2 (Y221) pAb

Cat no: BS4055

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